gaba modulatorsmedical dictionary

Substances that do not act as agonists or antagonists but do affect the gaba receptor-ionophore complex. Gaba-a receptors (receptors, gaba-a) appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gaba-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. General anaesthetics probably act at least partly by potentiating gabaergic responses, but they are not included here.

(12 Dec 1998)

gaba agonists, gaba antagonists, GABA dehydrogenase < Prev | Next > GABA pathway, GABA permease, GABA receptor

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