VO4(3) Powerful inhibitor of many, but not all enzymes that cleave the terminal phosphate bond of ATP. The vanadate ion is believed to act as an analogue of the transition state of the cleavage reaction. Dynein is very sensitive to inhibition by vanadate, whereas kinesin is relatively insensitive. Similarly tyrosine kinases are sensitive to vanadate, but threonine/serine protein kinases are insensitive.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)

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