tumours definition

<immunology, oncology> Antigen on tumour cells detected by cell-mediated immunity. For virus transformed cells TSTA (unlike T antigen) is found to differ for different individual tumours induced by the same virus. May consist of fragments of T antigens exposed at the cell surface.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

American spelling: tumor specific antigen

(11 Mar 2008)

Surface antigen's of DNA tumour virus-transformed cells, which elicit an immune rejection of the virus-free cells when transplanted into an animal that has been immunised against the specific cell-transforming virus.

Acronym: TSTA

American spelling: tumor-specific transplantation antigens

(05 Mar 2000)

<oncology> The extent of the spread of a malignant neoplasm from its site of origin.

See: TNM staging.

American spelling: tumor stage

(05 Mar 2000)

<investigation>

A cytologic technique for measuring the functional capacity of tumour stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agent.

American spelling: tumor stem cell assay

(12 Dec 1998)

<cell biology> Colony-forming cells which give rise to neoplasms.

American spelling: tumor stem cells

(12 Dec 1998)

<molecular biology, oncology> A gene that encodes a product that normally negatively regulates the cell cycle and that must be mutated or otherwise inactivated before a cell can proceed to rapid division.

Examples: p53, RB retinoblastoma), WT 1 (Wilms' tumour), DCC (deleted in colonic carcinoma), NF 1 (neurofibrosarcoma) and APC adenomatous polyposis coli).

This entry appears with permission from the Dictionary of Cell and Molecular Biology

American spelling: tumor suppressor

(11 Mar 2008)

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American spelling: tumor suppressor gene