temperature sensemedical dictionary

The sensation of cold, heat, coolness, and warmth.

(12 Dec 1998)

temperature-sensitive mutantmedical dictionary

A viral mutant that is able to replicate at one portion of a temperature range but not at another, the parent (wild type) strain being able to replicate over the whole temperature range.

Compare: cold-sensitive mutant, quick-stop mutant.

(05 Mar 2000)

temperature sensitive mutationmedical dictionary

<genetics, molecular biology> A type of conditional mutation in organism, somatic cell or virus that makes it possible to study genes whose total inactivation would be lethal. Such ts mutations can also make possible studies of the effect of reversible switching by temperature changes) in expression of the mutated gene. The usual mechanism of temperature sensitivity is that the mutated gene codes for a protein with a temperature dependent conformational instability, so that it possesses normal activity at one temperature (the permissive temperature), but is inactive at a second (nonpermissive) temperature.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)

temperature spotmedical dictionary

One of a number of definitely arranged spot's on the skin sensitive to heat and cold, but not to ordinary pressure or pain stimuli.

(05 Mar 2000)