suppressor mutationmedical dictionary

<molecular biology> Mutation that alleviates the effect of a primary mutation at a different locus.

May be through almost any mechanism that can give a primary mutation, but perhaps the most interesting class are the amber and ochre supressors, where the anticodon of the tRNA is altered so that it mis reads the termination codon and inserts an amino acid, preventing premature termination of the peptide chain.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)