Methyl nitroso urea with a 2 substituted glucose, used as an antibiotic (effective against growing gram-positive and gram-negative organisms) and also to induce a form of diabetes in experimental animals (rapidly induces pancreatic B-cell necrosis if given in high-dose). By using multiple low doses in a particular strain of mice, it is possible to produce insulitis followed later by diabetes, a model for juvenile onset diabetes in humans.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
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