|rolling circle mechanism||medical dictionary|
DNA synthesis starts with a cut in the + strand at the replication origin, the 5' end rolls out and replication starts at the 3' side of the cut around the intact circular DNA strand. Replication of the 5' end (tail) takes place by the formation of Okazaki fragments.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
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