ribonucleasemedical dictionary

<biochemistry, enzyme, molecular biology> Widely distributed type of enzyme that cleaves RNA. May act as endonucleases or exonucleases depending upon the type of enzyme. Generally recognise target by tertiary structure rather than sequence.

Ribonuclease E is involved in the formation of 5S ribosomal RNA from pre rRNA.

Ribonuclease F is stimulated by interferons and cleaves viral and host RNA and thus inhibits protein synthesis.

Ribonuclease H specifically cleaves an RNA base paired to a complementary DNA strand.

Ribonuclease P is an endonuclease that generate t RNA from their precursor transcripts.

Ribonuclease T is an endonuclease that removes the terminal AMP from the 3' CCA end of a nonaminoacylated tRNA. Ribonuclease T1 cleaves RNA specifically at guanosine residues. Ribonuclease TIII cleaves double stranded regions of RNA molecules.

Acronym: RNase

(23 Aug 1998)