prothrombin -->
factor II
medical dictionary

<haematology> A protein which is synthesised by the liver.

Fibrinogen is converted to fibrin, in the formation of a blood clot, via the enzymatic action of thrombin. A fibrinogen assay measures the concentration of fibrinogen in the blood and may be used to evaluate abnormal blood clotting.

A lack of fibrinogen may be congenital or acquired. A condition known as DIC results in the excessive utilisation and depletion of fibrinogen.

Synonyms: thrombin.

(15 Nov 1997)