protein p34cdc2medical dictionary

Phosphoprotein with protein kinase activity that functions in the g2/m phase transition of the cell cycle. It is the catalytic subunit of the maturation-promoting factor and complexes with both cyclin a and cyclin b in mammalian cells. The maximal activity of p34cdc2 is achieved when it is fully dephosphorylated. Protein p34cdc2, the product of the cdc2 gene in schizosaccharomyces pombe, should not be confused with the unrelated product of the cdc2 gene in saccharomyces cerevisiae that forms the large subunit of DNA polymerase III.

(12 Dec 1998)