A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralise the anticoagulant action of heparin in the treatment of heparin overdose.
Pharmacological action: heparin antagonists.
(12 Dec 1998)
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