phosphomannose -->
mannose-6-phosphate
medical dictionary

<biochemistry> Mannose derivative formed by phosphorylation in the Golgi complex of certain mannose residues on N glycan chains of lysosomal enzymes.

Believed to function as targetting signal that causes entry of these enzymes to the lysosomes. The receptor (215 kD) is enriched in specialised pre lysosomes.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)