phosphodiesterasemedical dictionary

<enzyme>

<cell biology> An enzyme that cleaves phosphodiesters to give a phosphomonoester and a free hydroxyl group.

Examples include RNase, DNase, phospholipases C and D and the enzymes that convert cyclic nucleotides to the monoester forms. In casual usage the cAMP phosphodiesterase is usually meant.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)