peptidase P -->
peptidyl-dipeptidase A
medical dictionary

<enzyme>

<cell biology> A hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine.

An important step in the metabolism of certain vasopressor agents.

It is a chloride-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. Only single dipeptides are released from angiotensin I and bradykinin because of the lack of activity on bonds involving proline. It may also have endopeptidase activity on some substrates.

Registry number: EC 3.4.15.1

Synonyms: carboxycathepsin, dipeptidyl carboxypeptidase, kinase II, peptidase P.

(22 Sep 2002)