Intermediate in the de novo synthesis of pyrimidines. Linked glycosidically to ribose 5' phosphate, orotate forms the pyrimidine nucleotide orotidylate, that on decarboxylation at position 5 of the pyrimidine ring yields the major nucleotide uridylate (uridine 5' phosphate).

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)

orosomucoid, orotate, orotate phosphoribosyltransferase < Prev | Next > orotic aciduria, orotidine

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