nitric oxide synthasemedical dictionary


<cell biology> An enzyme that catalyses the conversion of l-arginine, NADPH, and oxygen to citrulline, nitric oxide, and NADP+.

The enzyme found in brain, but not that induced in lung or liver by endotoxin, requires calcium.There are two isoforms, one constitutive and one activated by calmodulin.

Chemical name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

Registry number: EC

Acronym: NOS

(12 Dec 1998)