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Genes identified in studies of vertebrate neuronal development. Netrins are chemotropic for embryonic commisural neurones: netrin 1 is secreted by the floorplate, whereas netrin 2 is distributed ventrally except for the floorplate. The netrins are homologous to the product of unc 6, a gene identified in studies of neuronal development of the worm, Caenorhabditis elegans.

This entry appears with permission from the Dictionary of Cell and Molecular Biology

(11 Mar 2008)

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