|mismatch repair||medical dictionary|
<molecular biology> A DNA repair system that detects and replaces wrongly paired, mismatched, bases in newly replicated DNA. E. coli has a mismatch correction enzyme coded for by three genes mutH, mutL and mutS, that is directed to the newly synthesised strand and removes a segment of that strand including the incorrect nucleotide. The gap is then filled by DNA polymerase.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
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