macrocytosismedical dictionary

<haematology> Macrocytosis is enlargement of the red blood cells as defined by a red cell mean corpuscular volume (MCV) of greater than 100 fl.

Macrocytosis is present in 1 to 4 % of the adult population. The most common cause is alcoholism. Other causes include: nutritional deficiencies (B12 and folate), chemotherapy, drug side effects, haemolysis, liver dysfunction, myelodysplasia and hypothyroidism.

(27 Jan 1998)