dictionary help| immunoglobulin class switching | medical dictionary |
Gene rearrangement of the b-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
(12 Dec 1998)
immunoglobulin, immunoglobulin A, immunoglobulin allotypes < Prev | Next > immunoglobulin constant region, immunoglobulin D
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