human a1-proteinase inhibitor -->
a1-antitrypsin
medical dictionary

A glycoprotein that is the major protease inhibitor of human serum, is synthesised in the liver, and is genetically polymorphic due to the presence of over 20 alleles; individuals appropriately homozygous are deficient in a1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein. A1-Antitrypsin also inhibits thrombin.

Synonyms: a1-trypsin inhibitor, human a1-proteinase inhibitor.

(05 Mar 2000)

a-, A-0, a1, a1-acid glycoprotein < Prev | Next > a1-lipoprotein, a1PI, A1 security

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