glycyrrhizic acidmedical dictionary


A widely used anti-inflammatory agent isolated from the licorice root. It is metabolised to glycyrrhetic acid, which inhibits 11 beta-hydroxysteroid dehydrogenase and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, oedema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.

Pharmacological action: anti-infective agents, non-steroidal anti-inflammatory agents, antifungal agents, antiviral agents.

Chemical name: alpha-D-glucopyranosiduronic acid, (3 beta,20 beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-

(12 Dec 1998)

glycylprolyl dipeptidase, glycyrrhetinic acid, glycyrrhiza < Prev | Next > glycyrrhizimic, glycyrrhizin

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