It is made by the action of nitric acid on glycerin in the presence of sulphuric acid. It is extremely unstable and terribly explosive. A very dilute solution is used in medicine as a neurotic under the name of glonion.
A great number of explosive compounds have been produced by mixing nitroglycerin with different substances; as, dynamite, or giant powder, nitroglycerin mixed with siliceous earth; lithofracteur, nitroglycerin with gunpowder, or with sawdust and nitrate of sodium or barium; Colonia powder, gunpowder with nitroglycerin; dualin, nitroglycerin with sawdust, or with sawdust and nitrate of potassium and some other substances; lignose, wood fibre and nitroglycerin.
Pharmacologic action: Relaxes smooth muscle - dilates veins, dilates coronary arteries, reduces left ventricular filling pressure, lowers systemic vascular resistance, decreases myocardial oxygen demand.
Alternative forms: nitroglycerine.
Origin: Nitro- + glycerinn.
(17 Mar 2000)
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