<oncogene>

An oncogene, identified in a mouse osteosarcoma, encoding a transcription factor. The product of this oncogene works with the product of another oncogene, the jun oncogene, to abnormally change the rate of transcription of certain other genes.

Fos and jun proteins dimerise via a leucine zipper to form the AP 1 transcription factor.

(24 Mar 1998)

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