foreign body giant cellmedical dictionary

<pathology> Syncytium formed by the fusion of macrophages in response to an indigestible particle too large to be phagocytosed for example talc, silica or asbestos fibres).

There may be as many as 100 nuclei randomly distributed: similar cells but with the nuclei more peripherally located (Langhans cells) are found at the centre of tuberculous lesions.

(06 Mar 1998)