chloramphenicol o-acetyltransferasemedical dictionary

<enzyme>

<cell biology> An enzyme that catalyses the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria.

Chemical name: Acetyl-CoA-chloramphenicol 3-O-acetyltransferase

Registry number: EC 2.3.1.28

(12 Dec 1998)