calcium channel agonistmedical dictionary

<pharmacology> Agents that increase calcium influx into calcium channels of excitable tissues.

This causes vasoconstriction in vascular smooth muscle and/or cardiac muscle cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.

(12 Dec 1998)