bronchopulmonary aspergillosismedical dictionary

An inflammatory and destructive disease of the bronchi and lungs due to the presence and growth of Aspergillus fumigatus. There are four varieties: 1) a bronchial infection with allergic manifestations, in which the fungus grows in the mucus (evoked by the inflammation), which may be expectorated as yellow bronchial casts and may cause intermittent bronchial obstruction, with transient pulmonary shadows seen radiographically; asthma is often present, and bronchial wall destruction may eventually result in a proximal form of bronchiectasis; 2) aspergilloma; 3) an infection with pulmonary necrosis as a pneumonic involvement of the lung in debilitated subjects; 4) disseminated aspergillosis.

Synonyms: bronchopneumonic aspergillosis, pulmonary aspergillosis.

Disseminated aspergillosis, a variety of bronchopulmonary aspergillosis, characterised by a generalised infection of the lung with Aspergillus occurring usually in subjects with defective immune response.

Invasive aspergillosis, so-called because of the peculiar predilection of Aspergillus fumigatus to invade blood vessels and cause tissue infarction; it is second only to candidiasis as a cause of opportunistic fungal infection in patients whose immune mechanisms have been suppressed by chemotherapy.

(05 Mar 2000)