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["The Provisional BCL Manual", D. Hendry, U London 1966].

(01 Apr 2006)

BcgI methyltransferase, BCG vaccine, B chain, B chromosome < Prev | Next > bcl, bcl-2, bcl-3, BC NELIAC

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<oncogene>

Two variants of this oncogene are recognised.

1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9.

See: ced mutant.

2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA.

(24 Mar 1998)

BCG vaccine, B chain, B chromosome, BCL < Prev | Next > bcl-2, bcl-3, BC NELIAC, BCNU

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