atebrine hydrochloride -->
quinacrine hydrochloride
medical dictionary

An acridine derivative, C23H30ClN3O-2HCl-2H2O, used as an antimalarial that destroys the trophozoites of Plasmodium vivax and P. Falciparum, but does not affect the gametocytes, sporozoites, or exoerythrocytic stage of parasites; also used as an anthelmintic. As a dihydrochloride, it is used as a stain in cytogenetics to demonstrate Y chromatin by fluorescent microscopy. Quinacrine hydrochloride intercalates with DNA and also uncouples oxidative and photophosphorylation.

Synonyms: atebrine hydrochloride, mepacrine hydrochloride.

(05 Mar 2000)

quina, quinacrine, quinacrine chromosome banding stain < Prev | Next > quinacrine mustard, quinaldic acid

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