area under curvemedical dictionary

<pharmacology, statistics> A statistical means of summarizing information from a series of measurements on one individual.

It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. , producing a standard shape curve. It is a means of comparing the bioavailability of a drug.

A measure of how much of a drug reaches the bloodstream in a set period of time, usually 24 hours. The AUC is then calculated by plotting the concentration following a single dose of a drug against time at various points during a 24-hour or longer period and then measuring the area under the curve between 0 and 24 hours.

Acronym: AUC

(12 Jan 2009)