alpha-ketoglutaratemedical dictionary

A salt or ester of alpha-ketoglutaric acid.

Alpha-ketoglutarate dehydrogenase, an enzyme that catalyses the oxidative decarboxylation of 2-ketoglutaric acid to succinyldihydrolipoate; the succinyl group is later transferred to CoA and the reduced lipoate is oxidised by NAD+; a complex that is a part of the tricarboxylic acid cycle.

Synonyms: 2-oxoglutarate dehydrogenase, alpha-ketoglutarate dehydrogenase complex.

(05 Mar 2000)