Michaelis-Menten hypothesismedical dictionary

<chemistry> That a complex is formed between an enzyme and its substrate (the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (Brown hypothesis), the latter rate determining the overall rate of substrate-product conversion.

See: Michaelis-Menten constant, Michaelis-Menten equation.

(05 Mar 2000)