Holt-Oram syndromemedical dictionary


An inherited type of heart disease where there are defects in the internal walls (septa) between the atrium and ventricle chambers of the heart.

Holt-Oram syndrome is dominant (requires only one copy in the genome to be expressed) and is often associated with skeletal deformities such as abnormally short forearms or thumbs.

Inheritance: autosomal dominant.

(09 Oct 1997)